220.127.116.11 Chromium Picolinate. Found in vitamins and mineral supplements, Chromium may be necessary for utilization of dietary sugars and carbohydrates by optimizing the effects of insulin. "We want to make sure that consumers do not misinterpret this data," he tells WebMD. The dosage of chromium used in studies ranges from 200 mcg to 1,000 mcg daily, mostly in the form of chromium picolinate. "Our first study showed chromosome damage, and our second study has taken it one step further by showing that this damage leads to mutations," she says in a news release. In her study, Stearns exposed live hamster ovary cells to high dosages chromium picolinate and found a high incidence of mutated cells. A study led by the universities of Sydney and NSW has shown that living cells convert chromium III, a naturally occurring element used as a weight loss and type-2 diabetes treatment, into its âcarcinogenic cousinâ â hexavalent chromium, the industrial pollutant made notorious by the 2000 movie Erin Brockovich and a 2011 chemical spill near Newcastle. This creates an incredible cancer potential. Chromium Picolinate Cancer. Chromium picolinate and weight loss. Trivalent chromium is available as supplements while the latter is carcinogenic. And the issue is created with very little effort. Chromium is an essential mineral your body needs in small amounts. We conclude that the occurence of preputial gland adenomas in one group of male rats was possibly associated with exposure to chromium picolinate. However, there may be potential risks in the higher dosages of chromium (see Safety Issues). These obese individuals were given about 1000 Î¼g/day of chromium picolinate for 12 â 16 weeks. The investigations show that chromium picolinate resulted in very small amounts of weight loss (about 1.1 kg) after the treatment duration. Given that in vitro studies suggest that other forms of chromium used as nutritional supplements, such as chromium chloride, are unlikely to be susceptible to generating this type of oxidative damage, the use of these compounds, rather than Cr(pic)(3), would appear warranted. The demand for chromium pills -- often sold in the form of chromium picolinate -- is based on a simple and common premise: The mineral supposedly helps build muscle and burn fat. Nutrition 21 is the leading developer and marketer of chromium-based nutritional supplements. These medications are called oral medications. Within two weeks, the patient showed distinct improvement in signs and symptoms, blood sugar levels improved and insulin requirements were greatly reduced. It plays a role in how your body breaks down fats and carbohydrates. The element is needed only in trace amounts, but the U.S. Department of Agriculture (USDA) says that more than 90% of American diets contain less than the minimum recommended daily allowance of chromium and dietary sources are extremely poorly absorbed by the body. A safety paper published by the USDA comments on animal cell studies like Stearns,' citing "that one cannot extrapolate from a hamster tissue culture what could happen in humans," says Komorowski. P2. Stearns admits that the doses used in her study were higher than one would get from a few pills. We conclude that chromium picolinate did not cause cancer in female rats Now we find out that the body turns chromium-3 into chromium-6. It turns out that chromium side effects also include cancer â itâs very carcinogenic. The earliest study that showed the effect of chromium supplementation in decreasing symptoms of diabetes was done in the 1970s, when a patient was given supplemental chromium. You may require medicines together with healthy eating and exercise practices to handle your type 2 diabetes. A new study found that chromium is partially converted into a carcinogenic form when it enters cells (File photo) The mineral is primarily found in two forms. Chemists from the University of Alabama in Tuscaloosa, presented findings here today at the national meeting of the American Chemical Society, the world's largest scientific society, which they say show chromium(III) tris(picolinate) causes DNA breakage. Chromium is marketed as a protection against Type 2 diabetes and as a so-called "sugar balance" pill to help weight loss. Materials provided by American Chemical Society. American Chemical Society. The besâ¦ Chromium Picolinate Linked To Cancer. These and many other studies implicated chromium as a critical cofactor in insulin actioâ¦ ScienceDaily. What oral medicines treat type 2 diabetes? "There are studies that can be used to determine if a substance is toxic or not, and Nutrition 21 has done those studies, and chromium picolinate has been shown completely safe," he tells WebMD. All rights reserved. The Alabama studies advance the work of the late Dartmouth University chemist Karen Wetterhahn, Ph.D., who died from a widely publicized mercury-poisoning accident. New Treatments That May Change the Game, Understanding Cancer Diagnosis and Treatment. Glucose tolerance factor chromium, more commonly called chromium GTF, is a mineral that is frequently used in bodybuilding, athletic and weight-loss supplements. 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"Careful investigation into the effects of long-term diet supplementation with chromium picolinate are needed to evaluate its mutagenic and carcinogenic potentials. Chromium picolinate is an organic compound of trivalent chromium and picolinic acid, a naturally occurring derivative of tryptophan. Chromium is poorly absorbed following oral administration, but salt forms such as chromium picolinate, niacin-bound chromium, and chromium chloride, appear to have better bioavailability. Itâs been long known that chromium-6 is highly toxic. There are two forms of chromium: trivalent chromium and hexavalent chromium. In theory, this might mean chromium picolinate might cause cancer. The picolinic form increases Cr absorption from the GI tract, although this remains quite low, around 3%. One form, chromium picolinate, is popular because it is one of the more easily absorbed forms. "Chromium picolinate has been shown completely safe," says James Komorowski, MS, director of research and development at Nutrition 21 in Purchase, N.Y. â¦ You can take numerous diabetes medications by mouth. Conclusions. A nonprofit organization with a membership of nearly 159,000 chemists and chemical engineers, the American Chemical Society publishes scientific journals and databases, convenes major research conferences, and provides educational, science policy and career programs in chemistry. It often is an ingredient in products ranging from sports drinks and gum to pills. Chromium is believed to help the body process carbohydrates and fats.1ï»¿ It is marketed as a weight loss aid for dieters and an ergogenic (muscle-building) aid for bodybuilders and athletes. When Chromium Picolinate is taken as a dietary supplement with Vitamin C supplements, it caused genetic damage to laboratory hamsters. In addition, development of other readily absorbable sources of chromium that lack the DNA-damaging ability of chromium picolinate seems warranted.". . You can take numerous diabetes medications by mouth. Vincent found that chromium picolinate reacts with common biochemicals, like vitamin C. He says the products "can then catalyze a reaction with oxygen to generate the potent DNA-damaging hydroxyl radical." Note: Content may be edited for style and length. Renger F. Witkamp, in Comprehensive Natural Products II, 2010. Dec. 11, 2001 -- A popular nutritional supplement, chromium picolinate, has been touted as a fix for weight loss and muscle growth, a potion to help you lose body fat. Chromium picolinate is claimed to reduce body fat and build muscle. When combined with picolinic acid, it is referred to as chromium picolinate and is sold as a nutritional supplement. Until now, though, there was no solid explanation for just how chromium picolinate caused the damage. (1999, March 24). Still, chromium's role in these processes is not well understood. Chromium is a trace mineral found in two main forms, trivalent chromium (III) and hexavalent chromium (VI). Such events are known, in some cases, to cause genetic mutations and cancer in humans, the researchers noted. Research on the benefits of chromium to enhance fat loss and increase performance in bodybuilders and athletes has provided mixed results. A few studies have even suggested that very high chromium levels can cause DNA damage and may cause cancer. Other novel chromium compounds also have improved bioavailability (40) (41) . ANAHEIM, Calif., March 23 --New evidence has been reported that a popular nutritional and dietary supplement, called chromium picolinate, may be a cancer risk. We are looking at the potential, at a chemical level, if it is possible that [chromium picolinate] is a mutagen, and the answer is yes." Most trials used chromium picolinate, and others used chromium-enriched yeast or chromium nicotinate. Popular Diet Supplement May Be A Cancer Risk. WebMD does not provide medical advice, diagnosis or treatment. Nutrition 21's studies have focused on weight loss, cholesterol, and diabetes. Hexavalent chromium compounds have been used as corrosion inhibitors in a wide variety of products and processes. Chromium picolinate works together with insulin produced by the pancreas to metabolize carbohydrates. But one chromium manufacturer says it has conducted extensive human tests. "Also, it is known that chromium can accumulate in the body; therefore, we caution against taking excessive doses of chromium picolinate for long periods of time. gland was greater in male rats receiving 10,000 ppm chromium picolinate than in the control group. Chromium (in the form chromium picolinate or CrPic) has been associated with a reduction in the risk for obesity, less weight gain and may positively affect food intake. This article examines the evidence to determine the benefits of chromium picolinate. What oral medications deal with type 2 diabetes? Chromium picolinate is a nutritional supplement derived by combining chromium and picolinic acid. ", Stearns found that 58 of 1 million cells had DNA damage, Komorowski points out. This was due to concerns raised by the Expert Group on Vitamins and Minerals that chromium(III) picolinate might be genotoxic (cause cancer). Chromium picolinate, on the other hand, is more readily taken in during digestive processes. Chronic inhalation of chromium-6 has been shown to increase the risk of lung cancer and â¦ You may require medications along with healthy consuming and exercise routines to manage your type 2 diabetes. Studies show chromium supplementation can improve mood, reduce cravings, improve insulin sensitivity, regulate blood glucose levels, and improve binge eating and depression symptoms. "They say her studies are 'extremely questionable.'". ", "I would definitely be concerned about taking this nutritional supplement based on what we've found," concludes Vincent. New Device Detects Which Hand Gesture You Want to Make, Key Advance for Printing Circuitry on Wearable Fabrics, Luminescent Wood Could Light Up Homes of the Future, Research Lays Groundwork for Ultra-Thin, Energy Efficient Photodetector on Glass. The FDA considers chromium picolinate a nutritional supplement and therefore does not regulate it. "Those doses are so high, she had to use acetone to get the chromium picolinate to go into solution, so you're using a toxic agent and mixing it with a huge dose of chromium picolinate and exposing it directly to ovary cells. 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